Journal article
Using magnetic resonance imaging to map the hidden burden of muscle involvement in systemic sclerosis
L Ross, A Lindqvist, B Costello, D Hansen, Z Brown, JA Day, W Stevens, A Burns, W Perera, M Pianta, A La Gerche, M Nikpour
Arthritis Research and Therapy | BMC | Published : 2022
Abstract
Background: Skeletal muscle can be directly affected by systemic sclerosis (SSc); however, a significant burden of SSc-associated myopathy is undetected because clinical parameters such as weakness and creatine kinase (CK) are unreliable biomarkers of muscle involvement. This study presents qualitative and quantitative magnetic resonance imaging (MRI) findings that quantify the prevalence of myopathy and evaluate any association between skeletal and cardiac muscle involvement in SSc. Methods: Thirty-two patients with SSc who fulfilled the 2013 American College of Rheumatology/European League Against Rheumatism classification criteria underwent skeletal muscle MRI in addition to cardiac MRI. ..
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Awarded by Eli Lilly and Company
Funding Acknowledgements
[ "This work was supported by a National Heart Foundation of Australia Vanguard Grant (Reference Number: 102206), Arthritis Australia -Australian Rheumatology Association Project Grant, Scleroderma Victoria Project Grant, St Vincent's Hospital Research Endowment Fund Project Grant (Reference number: 88371) and The University of Melbourne Research Establishment Grant.", "LR is supported by a MSK Australia PhD Scholarship and an Australian Government Research Training Program Scholarship. ZB is supported by a University of Melbourne Research Training Scholarship. JD holds a John T Reid Centenary Fellowship from the Walter and Eliza Hall Institute and a Clinical Investigator Award from the Sylvia and Charles Viertel Charitable Foundation. ALG is supported by an Australian National Heart Foundation Future Leader Fellowship (102021). MN holds a National Health and Medical Research Council of Australia Investigator Grant (GNT 1176538)." ]